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What to Know About the J&J COVID Vaccine Pause

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April 13, 2021 — After receiving studies of a uncommon blood clot in individuals receiving the Johnson & Johnson COVID-19 vaccine, the FDA and the CDC have beneficial a pause in using the vaccine, pending additional investigation.

Right here, what you’ll want to know:


Why was the pause recommended?

After reviewing knowledge, the businesses discovered six studies of people that skilled uncommon blood clots together with low platelets, that are the smallest blood cells and concerned in clotting. The six studies have been came upon of greater than 6.8 million doses given. The FDA and CDC initiated the pause ”out of an abundance of warning.”


What else is understood?

In accordance with a joint assertion issued by the CDC and FDA, all six circumstances have been in ladies between ages 18-48. Signs occurred 6-13 days after vaccination. The kind of clot is understood medically as a cerebral venous sinus thrombosis (CVST) and was seen together with low ranges of blood platelets. Go right here to be taught extra about these types of blood clots. 

Of the six circumstances, one girl died; one other was in important situation.

Remedy of this sort of clot is totally different from that for different sorts, the CDC and FDA say. Usually, an anticoagulant drug, heparin, is used. However for this sort of clot, different remedy could also be wanted.


Why does it occur?

“We do not have a definitive reply presently, however it seems to contain an immune response associated to the J&J vaccine that adversely impacts the operate of the platelets, which in flip prevents the conventional clotting course of from occurring,” says Robert Glatter, MD, emergency physician at Lenox Hill Hospital in New York Metropolis.

He says that the reason “could finally be associated to the adenovirus vector [used in the vaccine] itself.”


Why does it appear to have an effect on ladies greater than males?

That isn’t but recognized, says William Schaffner, MD, professor of preventive medication and infectious illness specialist at Vanderbilt College Medical Middle in Nashville. “This has been true for the AstraZeneca [vaccine] as properly and their blood clot points,” he says. Whether it is an immune-related problem, ladies do are inclined to have extra of these points than males, normally, he says.


What ought to individuals who received the J&J vaccine know and do?

Take into account that the studies of blood clots have been uncommon, Schaffner suggests. The possibilities are about 1 in one million, based mostly on the six studies out of 6.8 million doses given. “That is really a testomony to the sensitivity of our vaccine security system,” he says, that these few studies can be detected out of thousands and thousands of doses.

Individuals who have gotten the vaccine must be vigilant of signs, the FDA and CDC say. In the event you acquired the Johnson & Johnson vaccine and develop extreme headache, abdominal pain, leg ache, or shortness of breath inside 3 weeks of vaccination, contact your their well being care supplier.


How lengthy will the pause final?

That can be not but recognized. The CDC’s Advisory Committee on Immunization Practices (ACIP) will meet on Wednesday to additional evaluate the circumstances and ”assess their potential significance.” FDA can be reviewing the info additional.



WebMD Well being Information


Sources

CDC: “Joint CDC and FDA Assertion on Johnson & Johnson COVID-19 Vaccine.”

Johnson & Johnson: “Johnson & Johnson Assertion on COVID-19 Vaccine.”

William Schaffner, MD, professor of preventive medication and infectious illness specialist, Vanderbilt College Medical Middle, Nashville. 

Robert Glatter, MD, emergency doctor, Lenox Hill Hospital, New York Metropolis. 



© 2021 WebMD, LLC. All rights reserved.





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